Other News and Resources

Tuesday
Sep162014

Prevalence of asymptomatic malaria and bed net ownership and use in Bhutan, 2013: a country earmarked for malaria elimination


Results from a study published September 4 in Malaria Journal, on bednet ownership and use in Bhutan has reported the country appears on track toward malaria elimination! Among the findings, four sub-districts in Bhutan had very high coverage of long-lasting insecticide treated nets (LLINs), while two areas with historically high malaria incidence rates had shown continual decreases in cases reported through passive detection.

Read the full paper online here.

Tuesday
Sep162014

New Burnet Institute research uncovers proteins for effective malaria vaccines

Research from APMEN Partner Institution, Burnet Institute in Melbourne, Australia have uncovered a group of proteins that could form the basis for innovative diagnostics and effective vaccines against malaria. The findings, published in British Medical Journal, revealed several antigen-specific antibodies that were associated with active infection and protective immunity, which may be useful biomarkers to coordinate further research, particularly for P. vivax in the Asia Pacific region. 

Read the Burnet Institute media release here.

Tuesday
Sep162014

Measuring progress in global health

A special issue of Transactions of the Royal Society of Tropical Medicine & Hygiene, the 'Measuring Progress' series; a collection of papers published including Mnzava et al.'s Malaria vector control at a crossroads: public health entomology and the drive to elimination',will be available free online until the end of November 2014.

View the series here.

Tuesday
Sep162014

Understanding drug resistance in malaria parasites: Basic science for public health


CH Sibley has published in Molecular and Biochemical Parasitology  on malaria parasite, Plasmodium falciparum, and the ongoing struggle between evolution of resistance to antimalarials by the parasite and public health responses.

Read the abstract here.

Tuesday
Sep162014

Understanding drug resistance in malaria parasites: Basic science for public health


CH Sibley has published in Molecular and Biochemical Parasitology  on malaria parasite, Plasmodium falciparum, and the ongoing struggle between evolution of resistance to antimalarials by the parasite and public health responses.

Read the abstract here.

Tuesday
Sep162014

Prioritizing pregnant women in malaria endemic regions for bed nets from clinics


Donors, Ministries of Health, implementing agencies, and other partners should prioritise providing pregnant women in malaria endemic regions with long-lasting insecticide treated nets (LLINs) through antenatal care clinics to help prevent malaria and its adverse effects on mother and infant. Jenny Hill, from the Liverpool School of Tropical Medicine, and colleagues from the London School of Tropical Medicine and Hygiene, and the Malaria Control and Elimination Program at PATH in Seattle, explain that LLINs are a powerful public health tool to help improve maternal, neonatal, and infant health but that the use of these nets is well below national and international targets. 

Read & download the PLoS Medicine paper here.

Tuesday
Sep162014

ACT KNOW randomised trial for Plasmodium knowlesi malaria in Sabah, Malaysia

The study design protocol for a population-based case–control study in the state of Sabah, Malaysia has been published in British Medical Journal. The study will evaluate which factors lead to increased risk of acquiring human P. knowlesi malaria in two adjacent districts in Malaysian Borneo: Kudat and Kota Marudu. Information resulting from this study will assist in guiding public health strategies for malaria in this region and provide valuable human epidemiological data for integration with concurrent studies on the entomology, primatology and land use aspects of P. knowlesi transmission. Full Open Access paper here.

Monday
Aug252014

Characterizing, controlling and eliminating residual malaria transmission 

Kileen G.F. Malaria Journal 2014, 13:330

Abstract:

Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) interventions can 
reduce malaria transmission by targeting mosquitoes when they feed upon sleeping humans 
and/or rest inside houses, livestock shelters or other man-made structures. However, many 
malaria vector species can maintain robust transmission, despite high coverage of LLINs/IRS 
containing insecticides to which they are physiologically fully susceptible, because they 
exhibit one or more behaviours that define the biological limits of achievable impact with 
these interventions.

 

Tuesday
Aug192014

Cost analysis of the development and implementation of a spatial decision support system for malaria elimination in Solomon Islands

Marston et al. Malaria Journal 2014, 13:325 

Conclusion: This study provides the first cost analysis of an operational surveillance tool used specifically for malaria elimination in the South-West Pacific. It is demonstrated that the costs of such a decision support system are driven by specialized equipment and travel expenses. Such factors should be closely scrutinized in future programme budgets to ensure maximum efficiencies are gained and available resources are allocated effectively.

View/download the Malaria Journal pdf here.

Tuesday
Jul292014

Malaria vector control at crossroads: public health entomology and the drive to elimination

A recent article in Transactions of the Royal Society of Tropical Medicine by Mnzava et al. makes a crticial point about new opportunities to expand the role of those involved in vector control to perform as public health entomologists and contribute towards malaria elimination.

View/download the free full text article here.

Tuesday
Jul292014

Malaria policy advisory committee to the WHO: conclusions and recommendations of fifth biannual meeting (March 2014)

 

The Malaria Policy Advisory Committee to the World Health Organization (WHO) held its fifth meeting in Geneva, Switzerland from 12 to 14 March 2014. This article provides a summary of the discussions, conclusions and recommendations from that meeting.

View/download the free text article in Malaria Journal here.

 

Monday
Jul282014

Evaluation of community-based systems for the surveillance of day three-positive Plasmodium falciparum cases in Western Cambodia 

Delayed clearance of Plasmodium falciparum parasites is used as an operational indicator of potential artemisinin resistance. This study investigates the use of effective community-based systems to detect P. falciparum cases remaining positive 72 hours after initiating treatment.
Thursday
Jul242014

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Authors from the Global Burden of Disease Study 2013 have published their latest findings on global, regional, and national incidence and mortality of HIV, Tuberculosis and Malaria; the markers of Millenium Development Goal 6. Their findings credit a 38% decline in malaria incidence in central Asia since 2000, a result of regional malaria elimination efforts.

Access the abstract at The Lancet here.

 

Wednesday
Jul232014

Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat Province, Western Cambodia

Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient, but may promote the emergence and worsening of ART-resistance in sympatric P. falciparum populations. Here we show that CQ effectively treats P. vivax malaria in Pursat Province, Western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.

View/download the pdf from Antimicrobial Agents and Chemotherapy Journal here.

Monday
Jul212014

Eliminating Plasmodium falciparum in Hainan, China: a study on the use of behavioural change communication intervention to promote malaria prevention in mountain worker populations

 

Researchers from Hainan Provincial Center for Disease Control and Prevention have conducted an interventional study on behavioral change communication (BCC) strategy to promote mountain worker malaria prevention at a test site. This study found the methods and measures that are suitable for malaria prevention among mountain worker populations.

View/download the provisional pdf from Malaria Journal here.

Monday
Jul212014

Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax

Rapid, simple and cost-effective diagnostic tests that can be easily adapted and rapidly scaled-up at the field or community levels are needed. In this study, accelerated detection methods for the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) dihydrofolate reductase–thymidylate synthase were developed based on the loop-mediated isothermal amplification (LAMP) method. 

Download the pdf from Science Direct online here.

Monday
Jul212014

The Use of Artesunate Combination Therapy (Acts) and Long- Lasting Insecticidal Net (LLIN) in Low Endemic Area to Achieve Malaria Elimination in Indonesia

Indonesia’s three major malaria elimination goals include: 1) An annual parasite incidence (API) below 1 per 1000 population 2) Absence of indigenous cases, and 3) Active surveillance. Another key component of Indonesia’s elimination strategy includes the use of artesunate combination therapy (ACT) in place of chloroquine, because of evidence of widespread resistance.

This paper by Kusriastuti et al., published May 20 in new journal, Malaria Chemotherapy, Control and Elimination, details the results of a study assessing the impact of a new policy in malaria treatment using ACT in place of chloroquine together with long-lasting insecticidal net (LLINs) in the two areas of Sabang city in Aceh Province, located in the western part of Indonesia and in the Jembrana district, in Bali province. 

Read the full text of the paper online here.

Tuesday
Jul082014

Improving estimates of insecticide-treated mosquito net coverage from household surveys: using geographic coordinates to account for endemicity

This analysis of estimates of insecticide-treated nets (ITNs) coverage in 20 African countries proposes an approach that is not dependent on being able to identify malaria risk in a location during the survey design (since survey samples are typically selected on the basis of census sampling frames that do not include information on malaria zones), but rather being able to assign risk zones after a survey has already been completed. 

View/download the Malaria Journal pdf online here.

Friday
Jul042014

Surveillance-response systems: the key to elimination of tropical diseases

A priority research agenda within a ‘One Health-One World’ frame of global health was developed at The London Declaration on Neglected Tropical Diseases (NTDs), initiated by the World Health Organization. These priorities include;

(i) the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis, malaria and schistosomiasis;

(ii) development of new strategies, tools and approaches, such as improved diagnostics and antimalarial therapies;

(iii) rigorous validation of surveillance-response systems; and (iv) designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources.

 

Download the pdf journal article in Infectious Disease of Poverty here. (906 KB)

Wednesday
Jul022014

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin V (PMV).

This paper provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target. 

Read the Open Access paper in PLOS Biology here.