Other News and Resources

Monday
Aug252014

Characterizing, controlling and eliminating residual malaria transmission 

Kileen G.F. Malaria Journal 2014, 13:330

Abstract:

Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) interventions can 
reduce malaria transmission by targeting mosquitoes when they feed upon sleeping humans 
and/or rest inside houses, livestock shelters or other man-made structures. However, many 
malaria vector species can maintain robust transmission, despite high coverage of LLINs/IRS 
containing insecticides to which they are physiologically fully susceptible, because they 
exhibit one or more behaviours that define the biological limits of achievable impact with 
these interventions.

 

Tuesday
Aug192014

Cost analysis of the development and implementation of a spatial decision support system for malaria elimination in Solomon Islands

Marston et al. Malaria Journal 2014, 13:325 

Conclusion: This study provides the first cost analysis of an operational surveillance tool used specifically for malaria elimination in the South-West Pacific. It is demonstrated that the costs of such a decision support system are driven by specialized equipment and travel expenses. Such factors should be closely scrutinized in future programme budgets to ensure maximum efficiencies are gained and available resources are allocated effectively.

View/download the Malaria Journal pdf here.

Tuesday
Jul292014

Malaria vector control at crossroads: public health entomology and the drive to elimination

A recent article in Transactions of the Royal Society of Tropical Medicine by Mnzava et al. makes a crticial point about new opportunities to expand the role of those involved in vector control to perform as public health entomologists and contribute towards malaria elimination.

View/download the free full text article here.

Tuesday
Jul292014

Malaria policy advisory committee to the WHO: conclusions and recommendations of fifth biannual meeting (March 2014)

 

The Malaria Policy Advisory Committee to the World Health Organization (WHO) held its fifth meeting in Geneva, Switzerland from 12 to 14 March 2014. This article provides a summary of the discussions, conclusions and recommendations from that meeting.

View/download the free text article in Malaria Journal here.

 

Monday
Jul282014

Evaluation of community-based systems for the surveillance of day three-positive Plasmodium falciparum cases in Western Cambodia 

Delayed clearance of Plasmodium falciparum parasites is used as an operational indicator of potential artemisinin resistance. This study investigates the use of effective community-based systems to detect P. falciparum cases remaining positive 72 hours after initiating treatment.
Thursday
Jul242014

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Authors from the Global Burden of Disease Study 2013 have published their latest findings on global, regional, and national incidence and mortality of HIV, Tuberculosis and Malaria; the markers of Millenium Development Goal 6. Their findings credit a 38% decline in malaria incidence in central Asia since 2000, a result of regional malaria elimination efforts.

Access the abstract at The Lancet here.

 

Wednesday
Jul232014

Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat Province, Western Cambodia

Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient, but may promote the emergence and worsening of ART-resistance in sympatric P. falciparum populations. Here we show that CQ effectively treats P. vivax malaria in Pursat Province, Western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.

View/download the pdf from Antimicrobial Agents and Chemotherapy Journal here.

Monday
Jul212014

Eliminating Plasmodium falciparum in Hainan, China: a study on the use of behavioural change communication intervention to promote malaria prevention in mountain worker populations

 

Researchers from Hainan Provincial Center for Disease Control and Prevention have conducted an interventional study on behavioral change communication (BCC) strategy to promote mountain worker malaria prevention at a test site. This study found the methods and measures that are suitable for malaria prevention among mountain worker populations.

View/download the provisional pdf from Malaria Journal here.

Monday
Jul212014

Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax

Rapid, simple and cost-effective diagnostic tests that can be easily adapted and rapidly scaled-up at the field or community levels are needed. In this study, accelerated detection methods for the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) dihydrofolate reductase–thymidylate synthase were developed based on the loop-mediated isothermal amplification (LAMP) method. 

Download the pdf from Science Direct online here.

Monday
Jul212014

The Use of Artesunate Combination Therapy (Acts) and Long- Lasting Insecticidal Net (LLIN) in Low Endemic Area to Achieve Malaria Elimination in Indonesia

Indonesia’s three major malaria elimination goals include: 1) An annual parasite incidence (API) below 1 per 1000 population 2) Absence of indigenous cases, and 3) Active surveillance. Another key component of Indonesia’s elimination strategy includes the use of artesunate combination therapy (ACT) in place of chloroquine, because of evidence of widespread resistance.

This paper by Kusriastuti et al., published May 20 in new journal, Malaria Chemotherapy, Control and Elimination, details the results of a study assessing the impact of a new policy in malaria treatment using ACT in place of chloroquine together with long-lasting insecticidal net (LLINs) in the two areas of Sabang city in Aceh Province, located in the western part of Indonesia and in the Jembrana district, in Bali province. 

Read the full text of the paper online here.

Tuesday
Jul082014

Improving estimates of insecticide-treated mosquito net coverage from household surveys: using geographic coordinates to account for endemicity

This analysis of estimates of insecticide-treated nets (ITNs) coverage in 20 African countries proposes an approach that is not dependent on being able to identify malaria risk in a location during the survey design (since survey samples are typically selected on the basis of census sampling frames that do not include information on malaria zones), but rather being able to assign risk zones after a survey has already been completed. 

View/download the Malaria Journal pdf online here.

Friday
Jul042014

Surveillance-response systems: the key to elimination of tropical diseases

A priority research agenda within a ‘One Health-One World’ frame of global health was developed at The London Declaration on Neglected Tropical Diseases (NTDs), initiated by the World Health Organization. These priorities include;

(i) the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis, malaria and schistosomiasis;

(ii) development of new strategies, tools and approaches, such as improved diagnostics and antimalarial therapies;

(iii) rigorous validation of surveillance-response systems; and (iv) designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources.

 

Download the pdf journal article in Infectious Disease of Poverty here. (906 KB)

Wednesday
Jul022014

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin V (PMV).

This paper provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target. 

Read the Open Access paper in PLOS Biology here.

Wednesday
Jul022014

NY Times: How to Beat Malaria, Once and For All

Professor of tropical medicine at the University of Oxford and the director of the Shoklo Malaria Research Unit, François H. Nosten, recently penned an Op-Ed in the NY Times entitled, "How to Beat Malaria, Once and For All".

View the online piece here.

Wednesday
Jul022014

Progress in mosquito net coverage in Papua New Guinea

This study investigated changes in mosquito net ownership and use following the continued free distribution of LLINs across PNG.

View/download the Malaria Journal pdf here.

 

Tuesday
Jul012014

Relative Roles of Weather Variables and Change in Human Population in Malaria: Comparison over Different States of India

Malaria depends on vector abundance which, in turn, depends on a combination of weather variables
This paper considered the 28 states of India, characterized by diverse climatic zones and changing population as well as complex variability in malaria, as a natural test bed.
An analysis of potential malaria load was measured based on the number of vector genesis (due to ecological factors), changes in the human population, compared with the reported number of malaria cases. Future research could predict climate change effects on malaria cases.
Wednesday
Jun252014

A molecular survey of febrile cases in malaria-endemic areas along China-Myanmar border in Yunnan province, People’s Republic of China

A molecular survey of febrile patients with a history of traveling abroad along the Myanmar-China endemic border areas from January 2008 to August 2012 was carried out. The rates of infection with species of Plasmodium and compliance of microscopy diagnosis with nested PCR (Polymerase Chain Reaction) results were calculated.
Tuesday
Jun242014

Malaria control in Nepal 1963-2012: challenges on the path towards elimination

 

Malaria is still a priority public health problem of Nepal where about 84% of the population are at risk.

This paper highlights the past and present malaria situation in Nepal and its challenges for long-term malaria elimination strategies.

View/download the Malaria Journal article here.

Wednesday
Jun182014

Participants’ perceptions and understanding of a malaria clinical trial in Bangladesh 

In this paper, the authors seek to understand how well patients involved in a clinical study of malaria in Bangladesh understand the patient information sheet or the informed consent procedure, or their rights in relation to an uncomplicated malaria study.

Read the full text article in Malaria Journal here.


Wednesday
Jun182014

A review of malaria transmission dynamics in forest ecosystems

A summary of the various topographical, entomological, parasitological, human ecological and socio-economic factors, which are crucial and shape malaria transmission in forested areas, including forested and deforested regions in Asia.

View/download the Parasite and Vectors Journal article here.