Other News and Resources

Wednesday
Jul232014

Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat Province, Western Cambodia

Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient, but may promote the emergence and worsening of ART-resistance in sympatric P. falciparum populations. Here we show that CQ effectively treats P. vivax malaria in Pursat Province, Western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.

View/download the pdf from Antimicrobial Agents and Chemotherapy Journal here.

Monday
Jul212014

Eliminating Plasmodium falciparum in Hainan, China: a study on the use of behavioural change communication intervention to promote malaria prevention in mountain worker populations

 

Researchers from Hainan Provincial Center for Disease Control and Prevention have conducted an interventional study on behavioral change communication (BCC) strategy to promote mountain worker malaria prevention at a test site. This study found the methods and measures that are suitable for malaria prevention among mountain worker populations.

View/download the provisional pdf from Malaria Journal here.

Monday
Jul212014

Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax

Rapid, simple and cost-effective diagnostic tests that can be easily adapted and rapidly scaled-up at the field or community levels are needed. In this study, accelerated detection methods for the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) dihydrofolate reductase–thymidylate synthase were developed based on the loop-mediated isothermal amplification (LAMP) method. 

Download the pdf from Science Direct online here.

Monday
Jul212014

The Use of Artesunate Combination Therapy (Acts) and Long- Lasting Insecticidal Net (LLIN) in Low Endemic Area to Achieve Malaria Elimination in Indonesia

Indonesia’s three major malaria elimination goals include: 1) An annual parasite incidence (API) below 1 per 1000 population 2) Absence of indigenous cases, and 3) Active surveillance. Another key component of Indonesia’s elimination strategy includes the use of artesunate combination therapy (ACT) in place of chloroquine, because of evidence of widespread resistance.

This paper by Kusriastuti et al., published May 20 in new journal, Malaria Chemotherapy, Control and Elimination, details the results of a study assessing the impact of a new policy in malaria treatment using ACT in place of chloroquine together with long-lasting insecticidal net (LLINs) in the two areas of Sabang city in Aceh Province, located in the western part of Indonesia and in the Jembrana district, in Bali province. 

Read the full text of the paper online here.

Tuesday
Jul082014

Improving estimates of insecticide-treated mosquito net coverage from household surveys: using geographic coordinates to account for endemicity

This analysis of estimates of insecticide-treated nets (ITNs) coverage in 20 African countries proposes an approach that is not dependent on being able to identify malaria risk in a location during the survey design (since survey samples are typically selected on the basis of census sampling frames that do not include information on malaria zones), but rather being able to assign risk zones after a survey has already been completed. 

View/download the Malaria Journal pdf online here.

Friday
Jul042014

Surveillance-response systems: the key to elimination of tropical diseases

A priority research agenda within a ‘One Health-One World’ frame of global health was developed at The London Declaration on Neglected Tropical Diseases (NTDs), initiated by the World Health Organization. These priorities include;

(i) the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis, malaria and schistosomiasis;

(ii) development of new strategies, tools and approaches, such as improved diagnostics and antimalarial therapies;

(iii) rigorous validation of surveillance-response systems; and (iv) designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources.

 

Download the pdf journal article in Infectious Disease of Poverty here. (906 KB)

Wednesday
Jul022014

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin V (PMV).

This paper provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target. 

Read the Open Access paper in PLOS Biology here.

Wednesday
Jul022014

NY Times: How to Beat Malaria, Once and For All

Professor of tropical medicine at the University of Oxford and the director of the Shoklo Malaria Research Unit, François H. Nosten, recently penned an Op-Ed in the NY Times entitled, "How to Beat Malaria, Once and For All".

View the online piece here.

Wednesday
Jul022014

Progress in mosquito net coverage in Papua New Guinea

This study investigated changes in mosquito net ownership and use following the continued free distribution of LLINs across PNG.

View/download the Malaria Journal pdf here.

 

Tuesday
Jul012014

Relative Roles of Weather Variables and Change in Human Population in Malaria: Comparison over Different States of India

Malaria depends on vector abundance which, in turn, depends on a combination of weather variables
This paper considered the 28 states of India, characterized by diverse climatic zones and changing population as well as complex variability in malaria, as a natural test bed.
An analysis of potential malaria load was measured based on the number of vector genesis (due to ecological factors), changes in the human population, compared with the reported number of malaria cases. Future research could predict climate change effects on malaria cases.
Wednesday
Jun252014

A molecular survey of febrile cases in malaria-endemic areas along China-Myanmar border in Yunnan province, People’s Republic of China

A molecular survey of febrile patients with a history of traveling abroad along the Myanmar-China endemic border areas from January 2008 to August 2012 was carried out. The rates of infection with species of Plasmodium and compliance of microscopy diagnosis with nested PCR (Polymerase Chain Reaction) results were calculated.
Tuesday
Jun242014

Malaria control in Nepal 1963-2012: challenges on the path towards elimination

 

Malaria is still a priority public health problem of Nepal where about 84% of the population are at risk.

This paper highlights the past and present malaria situation in Nepal and its challenges for long-term malaria elimination strategies.

View/download the Malaria Journal article here.

Wednesday
Jun182014

Participants’ perceptions and understanding of a malaria clinical trial in Bangladesh 

In this paper, the authors seek to understand how well patients involved in a clinical study of malaria in Bangladesh understand the patient information sheet or the informed consent procedure, or their rights in relation to an uncomplicated malaria study.

Read the full text article in Malaria Journal here.


Wednesday
Jun182014

A review of malaria transmission dynamics in forest ecosystems

A summary of the various topographical, entomological, parasitological, human ecological and socio-economic factors, which are crucial and shape malaria transmission in forested areas, including forested and deforested regions in Asia.

View/download the Parasite and Vectors Journal article here.

Wednesday
Jun182014

Measuring the path toward malaria elimination: Defining new targets and milestones for from standard surveillance data 

A group of authors discuss broadening the definition of malaria elimination to consider appropriate metrics needed to ascertain progress toward malaria elimination.

View/download the Science Magazine article pdf here.

Wednesday
Jun182014

Challenges in universal coverage and utilization of insecticide-treated bed nets in migrant plantation workers in Myanmar

The paper addresses issues regarding population of vulnerable, high risk migrant workers. Efforts to improve effective utilization of ITNs provided by continuous mass free distribution, should include durability monitoring, surveillance of insecticide resistance of the vector and behaviour change interventions in migrant plantation workers.

Wednesday
May282014

First Evaluation of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Vivax Malaria Endemic Regions in the Republic of Korea

Wednesday
May282014

Importance of active case detection in a malaria elimination programme

Wednesday
May282014

Asymptomatic Plasmodium falciparum Malaria in Pregnant Women in the Chittagong Hill Districts of Bangladesh 

Wednesday
May142014

The role of vector control in stopping the transmission of malaria: threats and opportunities

Read the full free article in Royal Society Biological Sciences.