Other News and Resources
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Authors from the Global Burden of Disease Study 2013 have published their latest findings on global, regional, and national incidence and mortality of HIV, Tuberculosis and Malaria; the markers of Millenium Development Goal 6. Their findings credit a 38% decline in malaria incidence in central Asia since 2000, a result of regional malaria elimination efforts.
Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat Province, Western Cambodia
Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient, but may promote the emergence and worsening of ART-resistance in sympatric P. falciparum populations. Here we show that CQ effectively treats P. vivax malaria in Pursat Province, Western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.
Eliminating Plasmodium falciparum in Hainan, China: a study on the use of behavioural change communication intervention to promote malaria prevention in mountain worker populations
Researchers from Hainan Provincial Center for Disease Control and Prevention have conducted an interventional study on behavioral change communication (BCC) strategy to promote mountain worker malaria prevention at a test site. This study found the methods and measures that are suitable for malaria prevention among mountain worker populations.
Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax
Rapid, simple and cost-effective diagnostic tests that can be easily adapted and rapidly scaled-up at the field or community levels are needed. In this study, accelerated detection methods for the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) dihydrofolate reductase–thymidylate synthase were developed based on the loop-mediated isothermal amplification (LAMP) method.
The Use of Artesunate Combination Therapy (Acts) and Long- Lasting Insecticidal Net (LLIN) in Low Endemic Area to Achieve Malaria Elimination in Indonesia
Indonesia’s three major malaria elimination goals include: 1) An annual parasite incidence (API) below 1 per 1000 population 2) Absence of indigenous cases, and 3) Active surveillance. Another key component of Indonesia’s elimination strategy includes the use of artesunate combination therapy (ACT) in place of chloroquine, because of evidence of widespread resistance.
This paper by Kusriastuti et al., published May 20 in new journal, Malaria Chemotherapy, Control and Elimination, details the results of a study assessing the impact of a new policy in malaria treatment using ACT in place of chloroquine together with long-lasting insecticidal net (LLINs) in the two areas of Sabang city in Aceh Province, located in the western part of Indonesia and in the Jembrana district, in Bali province.
Improving estimates of insecticide-treated mosquito net coverage from household surveys: using geographic coordinates to account for endemicity
(i) the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis, malaria and schistosomiasis;
(ii) development of new strategies, tools and approaches, such as improved diagnostics and antimalarial therapies;
(iii) rigorous validation of surveillance-response systems; and (iv) designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources.
Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites
The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin V (PMV).
This paper provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target.
This study investigated changes in mosquito net ownership and use following the continued free distribution of LLINs across PNG.
Relative Roles of Weather Variables and Change in Human Population in Malaria: Comparison over Different States of India
A molecular survey of febrile cases in malaria-endemic areas along China-Myanmar border in Yunnan province, People’s Republic of China
Malaria is still a priority public health problem of Nepal where about 84% of the population are at risk.
In this paper, the authors seek to understand how well patients involved in a clinical study of malaria in Bangladesh understand the patient information sheet or the informed consent procedure, or their rights in relation to an uncomplicated malaria study.
A summary of the various topographical, entomological, parasitological, human ecological and socio-economic factors, which are crucial and shape malaria transmission in forested areas, including forested and deforested regions in Asia.
Measuring the path toward malaria elimination: Defining new targets and milestones for from standard surveillance data
A group of authors discuss broadening the definition of malaria elimination to consider appropriate metrics needed to ascertain progress toward malaria elimination.
Challenges in universal coverage and utilization of insecticide-treated bed nets in migrant plantation workers in Myanmar
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